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3D cultures such as organoids and spheroids together with orthotopic animal models of MB can be useful to study the mechanisms of resistance to therapy as well as the interaction with other components of the Tumor microenvironment and immune system ( Figure 1 )

Potent inhibition of human steroid 5alpha-reductase (EC 1.3.1.30) by 3-androstene-3-carboxylic acids.Bioorg.Med.Chem.1989,17, 372-376 81