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found that these hMOs exhibit greater cellular heterogeneity compared to the monolayer culture and a strong upregulation in hypoxia inducible factor 1 (HIF1) in SNCA-3 neurons [85], which has been associated with PD and brain aging [86]

151 Although long-term oral medications are frequently prescribed, they may cause side effects, including headache, nausea, vomiting, and possible toxicity to the liver and kidneys

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10.1046/j.1523-1747.2002.00077.x 82