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The pathophysiology is mainly manifested in the decrease of NPCs and the imbalance of synthesis and degradation of ECM of IVD

Mar 21 2013;495(7441):360-4

Because B12 shots are administered intramuscularly, they bypass the digestive system, allowing the body to absorb a much larger amount of B12 that would otherwise be lost during digestion

In detail, bioinformatic analysis of several databases of MB suggested that the lower the level of VEGFC expression in the WNT MB group, the worse the outcome of patients