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Apart from ROS being created as a result of oxidative glucose metabolism, the constant exposure of retinal cells to sunlight and artificial light triggers the production of ROS 16,17 , especially with photosensitizers present, such as retinoids 16,18 , and leads to photo-oxidation 19

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Emma F, Nesterova G, Langman C, Labbe A, Cherqui S, Goodyer P, Janssen MC, Greco M, Topaloglu R, Elenberg E, Dohil R, Trauner D, Antignac C, Cochat P, Kaskel F, Servais A, Wuhl E, Niaudet P, Vant Hoff W, Gahl W, Levtchenko E (2014) Nephropathic cystinosis: an international consensus document

from the UK reported a clinical trial that showed improvement in skin collagen, hydration, elasticity, wrinkles, and scalp and hair parameters following the oral intake of a supplement called Absolute Collagen, containing hydrolyzed collagen (8 g) and vitamin C (60 mg) daily for 12 weeks in men and women (aged 4060 years) [51]

Inconsistent results Inconsistent response usually indicates inconsistent administration