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Lett Appl Microbiol 40:378384 Noguti J, Barbisan LF, Cesar A, Dias Seabra C, Choueri RB, Ribeiro DA (2012) Review: in vivo models for measuring placental glutathione-S-transferase (GST-P7-7) levels: a suitable biomarker for understanding cancer pathogenesis

The cytoprotective role of the Keap1-Nrf2 pathway

Genetic and metabolic studies have further shown that metabolites such as succinate and fumarate, which are generated under normal physiological conditions, are associated with tumorigenesis in several cancer types

70 As cells use NADPH to reduce cystine to cysteine, the increased cysteine catabolism by CDO implies the increased consumption of NADPH, which will affect other cell metabolic pathways and the antioxidant capacity as well

This stress can initiate some catastrophic events in the cells such as lipid peroxidation, formation of DNA adducts, protein crosslinks, and the reduction of endogenous antioxidant levels in the liver 6