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To be accepted as a surrogate endpoint, a biomarker must demonstrate that changes in its levels reliably and reproducibly predict clinical benefit across multiple interventions and study populations, an evidentiary standard that few neurodegeneration-related markers currently meet [583]

The Canadian Perspective Canadian regulatory status for BPC-157 differs from some other jurisdictions

10.1016/j.neubiorev.2016.01.005 180 WildP.FarhanH.McewanD

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Groups at Yale University tested this approach with their lipid nanoparticle (LNP)-mRNA vaccines encoding the full-length spike of SARS-CoV-2 Delta, SARS-CoV-1, and MERS-CoV