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This polymorphism is associated with increased oxidative stress, which presents as an imbalance between pro-oxidant and antioxidant processes

doi: 10.1038/nrrheum.2016.217 69 RubicTLametschwandtnerGJostSHintereggerSKundJCarballido-PerrigNet al

A., Ahmad N., Tajurruddin F

Glutamate, a key neurotransmitter involved in the pathophysiology of schizophrenia and the regulation of sleep-wake neurobiology, plays a crucial role in mediating the quality of sleep, as evidenced by the correlation between sleep disturbances and glutamate levels in specific brain regions of individuals with schizophrenia

Transcriptomic analyses have shown upregulated expression of the ENPP2 gene (encoding ATX) in plasmacytoid dendritic cells (pDCs) from SLE patients, indicating increased intrinsic LPA-generating capacity within the immune compartment of patients