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1197 While the primary effects of rapamycin are attributed to alterations in T cells, it also inhibits BAFF-mediated mTORC1 signaling in B cells, thereby limiting their proliferation and survival

Giustina A, Misitano V, Voltz D, Piering A, Wehrenberg WB

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This structural deterioration increases the mechanical stress on the annulus fibrosus, eventually causing the nucleus pulposus to herniate through annular fissures, thereby initiating LDH (110)