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The results of several animal and clinical trials support these findings (24-26)

PMID: 16891118

While the potential of this axis is promising, significant scientific, technical, and clinical hurdles remain

Diabetologia 55 , 13661379 (2012)

Recombinant MANF treatment decreased HNF4 level with or without SBT induction, which may attenuate the effect of HNF4 on the mature hepatocytes and may be benefit for the transformation of mature hepatocytes into BECs or ICC cells