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Following up on their discovery, this same group of researchers tested the effects of 9-me-BC in vivo, by administering the drug intraperitoneally to rats for either 5 or 10 days, and testing their performance in the well-known spatial learning task, the radial arm maze

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Mice with inactivation of the urokinase plasminogen activator receptor (uPAR) gene, a key component of the HGF activation (Blasi, 1993), show diminished levels of HGF in cortical interneurons beginning at E16.5, indirectly suggesting that HGF has motogenic effects also on cortical interneuron precursors (Powell et al., 2001)

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When these become inflamed, you may have: Chest pain, Uneven heartbeat Fluid buildup around your lungs (pleuritis or pleurisy) Heart (pericarditis) Heart valve and lung problems, lleading to shortness of breath When to See Your Doctor If you develop new lupus symptoms or existing symptoms worsen, you should see your doctor