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Effects of tesamorelin, a growth hormone-releasing factor, in HIV-infected patients with abdominal fat accumulation: a randomized placebo-controlled trial with a safety extension

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The biphasic viral increase seen in mice can be explained by a partial block of virion production possibly due an early stage of innate immune response, reminiscent of the observed biphasic increase in chimpanzees that was suggested due to an endogenous type I interferon response (ibid)