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Three-and 7-month-old Tg4-42 and mice showed significantly decreased 18 F-FDG uptake in the hippocampus compared to WT mice (Fig

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*Correspondence: Jia Guo [email protected] These authors have contributed equally to this work Membership of the Alzheimer's Disease Neuroimaging Initiative This article was submitted to Neurocognitive Aging and Behavior, a section of the journal Frontiers in Aging Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers