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The NLR also has predictive value in the severity, prognosis, and diagnosis of HF, with its increased level being associated with a poor prognosis in patients with HF (162)

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In addition, a study showed that 5-azacitidine can significantly increase the tri-methylation of lysine-4 on histone H3 in mouse primary spermatocytes, which indicated that 5-azacitidine could modulate histone methylation (Burlibaa et al., 2021)