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Similarly, genistein, a soy-derived isoflavone, was found to reverse the hypermethylation of TSGs via a direct inhibition of DNA methyltransferase, suggesting these natural extracts could contribute to the chemoprevention of ESCC [145]

To analyze the enrichment of predicted shared tier-1 targets across all datasets among cellular metabolic pathways, we used the human metabolic model Recon2.2 to identify genes associated with each metabolic subsystem annotated in the model

Visceral obesity, metabolic syndrome, insulin resistance and cancer

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This evaluation encompasses: Data on the strength and potency of the investigated drug