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The increase in fasting nitrate/nitrite was influenced primarily by eight of the fourteen subjects receiving ALCA (Figure 4), highlighting the variability in response to dietary supplementation with L-carnitine in regards to blood nitrate/nitrite, a finding we have previously noted using glycine propionyl-L-carnitine [33]

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However, in obesity, excessive weight gain leads to white adipose tissue dysfunction, resulting in unregulated secretion of adipokines, including pro-inflammatory ones, fostering a chronic low-grade inflammatory state (99)