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However, successful clinical translation will require a deeper understanding of redox thresholds across cell types, subcellular compartments, and disease stages, as well as strategies to overcome compensatory antioxidant networks and systemic toxicity associated with non-specific redox modulation

45 demonstrated a seasonal effect in sheep with better oocyte quality results in spring than in autumn, although this study was carried out in prepubertal animals, where the endocrine profile is quite different from that of adults 46

10.1016/j.pneurobio.2016.04.001 95 Simes PiresE

Due to unpredictable rates of infection and diverse antigenic history, it is challenging to identify cohorts in which vaccine efficacy can be determined

Wang F, Guo Z, Li H, Mengmeng W, Yanhong Z