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However, understanding the theoretical framework helps professionals make informed decisions: Tirzepatide mechanism: Dual GIP/GLP-1 receptor agonist Already combines two incretin pathways Produces substantial weight loss (15-20% in clinical trials) Potential cagrilintide addition: Would add amylin pathway activation Could theoretically enhance gastric emptying delay Might increase satiety beyond tirzepatide alone Important consideration : Combining multiple appetite-suppressing peptides significantly increases the risk of gastrointestinal side effects

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GHRP-2 is more selective for GH release with less appetite stimulation and lower cortisol/prolactin effects than GHRP-6, making it useful for studying isolated GH secretion

10.7455/ijfs/2.1.2013.a3 Int