glutathione pathway yeast The in Saccharomyces cerevisiae. The synthesis of Glutathione production by non-Saccharomyces yeasts

BrnnerYFKofoetABenedictCFreiherrJ

B.WangQ

The obtained solid was washed with water and dried under a high vacuum to afford the 13.4 g (yield: 82%) of intermediate 2 as an off-white solid

Acknowledgements We acknowledge the DSFP contract, King Saud University, Riyadh, KSA (to SYA) and the Slovak Grant Agencies VEGA Project 1/0482/20 and APVV Project 19-0087

Ferroptosis is readily harnessed in cell culture, where it is induced by GSH depletion (e.g., by erastin) [58] or GPX4 inhibition (e.g., by RSL3) [49] and selectively rescued by potent radical trapping agents (e.g., ferrostatin and liproxstatin, which are not developed for human use) [59, 60]