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The details of the network between DSF, its targets, and modulated pathways are represented in Figure 3

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer

Such a thiol exchange mechanism enables proteome-wide profiling by enriching arsenic-bound proteins for mass spectrometry or imaging, with specificity enhanced by the probes design to minimize off-target monothiol interactions

Lastly, thorough preclinical and clinical head-to-head studies are needed to carefully explore different types of ferroptosis regulators and determine their therapeutic windows for various cancer types over longer experimental periods, in order to assess efficacy, drug compatibility, drug resistance, and related side effects