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At the same time 32% of those studied experienced adverse events, including liver dysfunction and one case of anaphylaxis (Alzahrani et al., Cureus 2025, PMID 40013212)

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In the NVU, endothelial cells are primarily responsible for the barrier functionality, with TJs between adjacent cells forming capillary walls in the CNS 9

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The results of immunofluorescence and Western blot showed that in the colon tissue of mice with acute colitis intervened with RSL3, the expression of GPX4 was positively correlated with HIF-1, while the expression of the other ferroptosis genes did not change significantly (Fig