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The inclusion criteria applied at this step were: use of acetylcysteine for acute acetaminophen overdose, use of acetylcysteine subsequent to a 4 to 24 hour acetaminophen level above the Rumack-Mathews treatment line (either the 150 line or the 200 line), no evidence of hepatotoxicity prior to acetylcysteine treatment, and a reported AST or ALT activity post acetylcysteine treatment

Abdominal visceral fat, which responds well to beta-3 adrenergic stimulation, appears particularly susceptible to the combination approach

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10.1038/nm.3681 20 NeunerS