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Indeed, the pharmacokinetic profile of those molecules can be extremely affected by this partitioning, and thus, the blood-to-plasma ratio could be opportunely assessed

Liu, Y., Lv, S., He, G., Wang, C

FIGURE 3 Tacrolimus, a calcineurin inhibitor with immunoregulatory and anti-inflammatory properties, has been shown to reverse disease progression in PAH rat models induced by MCT and hypoxia, restore pulmonary artery endothelial cell function, and activate BMPR2 receptor signaling by displacing FKBP12 from the BMPR1 co-receptor (Spiekerkoetter et al., 2013)

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SIRT3, located in the inner mitochondrial membrane, plays a crucial role in maintaining mitochondrial function