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6 Conclusion and outlook The intricate ferroptosis-immune-metabolic axis has emerged as a central driver of COPD pathogenesis, creating a self-perpetuating cycle of inflammation, oxidative stress, and tissue damage

The increased expression of UPR target genes, including ATF4 , DDIT3 , TRIB3 , GADD34 , uXBP1 , and sXBP1 , identified by RNA-seq, was validated in MNNG/HOS and U2OS cell lines using RT-qPCR (Fig

Knockdown of the 15 kDa Selenoprotein in HT-29 and HCT116 human colon cancer cell lines effectively halted both anchorage-dependent and anchorage-independent cell proliferation, which was achieved through the induction of a G0/G1 cell cycle arrest (207)