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Intestinal microbiota: A novel perspective in colorectal cancer biotherapeutics

While the System Xc-is considered the main source of Cys (LOU et al., 2022), studies suggest that Cys can also be synthesized through the sulfur transfer pathway when the System Xc-is inhibited (SHIMADA and STOCKWELL, 2015)

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2 The antioxidant mechanisms of NAC The antioxidant mechanisms of NAC are typically attributed to three main aspects: supplementing GSH, directly scavenging ROS, and reducing the disulfide bonds (Figure 1A)

Potential risks include: Insulin resistance Fluid retention Carpal tunnel-like symptoms Theoretical cancer signalling concerns with chronic GH elevation Unknown long-term effects Absence of long-term harm data is not the same as proof of safety