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However, in the case of relatively non-polar pharmaceuticals, GCMS without derivatization may be used (for instance in multi-residue analysis of pharmaceuticals, including carbamazepine, imipramine, dezipramine, doxepin, diazepam, and nordiazepam, in environmental samples (Togola and Budzinski 2008))

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M., Panavas, T., Brown, J