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Similarly, the specific activity of the peroxidase-like activity of the PSS-modified Ru nanozyme (2820 U/mg) is nearly twice that of HRP (1305 U/mg), and the detection sensitivity of Ru-ELISA is 140 times higher than that of HRP-ELISA in detecting human alpha-fetoprotein 139

We also conducted an updated systematic literature search for longitudinal studies reporting GMV changes in patients with depression following clinical treatment, covering publications up to June 2025