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showed evidence that Cu/Zn-superoxide dismutase (SOD, Sod1 / )-deficient mice showed muscle atrophy, weakness, and neuromuscular junction (NMJ) degeneration in early adulthood, similar to normal muscle aging, and the transgenic expression of SOD1 specifically prevented muscle mitochondrial function and calcium treatment defects in neurons of SOD1-deficient mice [53]

It is safe for daily and long-term use

320 , L508L521 (2021)

So, provided you're using proper hand washing technique, you can use hot water, warm water, cool water, or cold water and expect the same germ killing results