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For example, TNF-, IL-1, IL-6, IL-8 and IL-17A can stimulate inflammatory reactions in arthritic joints and synovial tissues (158, 188, 190), and play an important role in the development of RA

Three patients with BRIC-1 had compound heterozygous variant in the ATP8B1 gene and 1 had heterozygous while 2 patients with BRIC-2 had compound heterozygous in the ABCB11 gene and 1 had heterozygous

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