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this combined with what I assume is a lowered risk of OD from dope that is less fentanyl/analogues/nitazines/whatever, with those drugs in part being replaced with xylazine, which Im guessing has a lower fatal OD risk profile than the aforementioned synthetic opioids

Resolution of steatohepatitis and fibrosis reduction occurred in 32.7% of semaglutide-treated patients versus 16.1% in the placebo group (estimated difference 16.5 percentage points, 95% CI 10.222.8)

Inflammation markers like high-sensitivity C-reactive protein decline

Importantly, the animal study showed lower levels of ADAs in monkeys than in rats

However, due to its potent effects and the current stage of research, its application should be carefully considered within a clinical setting, guided by comprehensive testing and professional oversight