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(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]

229 Specifically, PKA modifies the open state of K-ATP channels through phosphorylation, affecting the cell membranes potential and intracellular calcium ion concentration

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