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Mathers Charitable Foundation, and is a Chan Zuckerberg Biohub Investigator

Pentose phosphate pathway The PPP, a critical branch of glucose metabolism, is highly active in cancer

Their mechanisms of action are rich and diverse, covering aspects such as interfering with cell wall/membrane synthesis, inhibiting virulence factors, disrupting energy metabolism, and regulating fungal signaling pathways (Lu et al., 2024

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This discovery prompted further investigation into other autophagy genes, uncovering more mutations, though less common, in important genes like UVRAG and ATG5