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Liver Take this medicine with caution if you have severe liver disease

7,40 CYP Members and Metabolites in Heart Failure and Remodeling Under physiological conditions, CYP450 enzymes in the cardiovascular system metabolize AA to EETs and hydroxyl eicosatetraenoic acids

Figure 1 2.3 Safety of human ingestion Considering the strict microbiome conditions necessary for UA production, the most efficient approach to harness the biological effects of UA is through in vitro synthesis followed by supplementation

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In human lymphocytes from healthy subjects, EGCG at concentrations of 1100 M induced dose-dependent DNA strand breaks (though no clastogenic effects were observed in vivo ) (Ouyang et al., 2020)