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The disruption of Golgi zinc homeostasis, whether through zinc depletion or transporter dysfunction, leads to unstacking of cisternae, vesiculation and fragmentation of the Golgi, impairing vesicle trafficking and protein sorting 73,135

But in the world of biochemistry, small changes can have massive ripple effects

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While larger models may generally offer better performance, our findings indicate that this reduced representation effectively captures complex clinical relationships while maintaining computational feasibility