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Unfortunately, to date, there are no therapies directly aimed at any of the fundamental biological mechanisms of aging [33]

During OA progression, the subchondral bone undergoes significant pathological changes: the early stage is characterized by active bone remodeling with increased bone resorption and formation, while the late stage shows reduced bone turnover with further diminished resorption and relatively predominant formation, leading to increased bone density, trabecular thickening, sclerosis, and subsequent osteophyte formation (Li X

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