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These E3 ligases associate with REV-ERB and mediate its ubiquitination, targeting it for proteasomal degradation following circadian cues such as lithium treatment or serum shock, both of which synchronize circadian oscillations in mammalian cells (Stojkovic et al., 2014

10.1124/dmd.116.070615 11 GianniniG.BaroneM

Ceruloplasmin-deficient mice show changes in PTM profiles of proteins involved in messenger RNA processing and neuronal projections and synaptic processes