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Current guidelines recommend anti-CD38 antibody-based triplet combinations for relapsed/refractory disease after one to three prior lines of therapy, incorporating previously unused agents for lenalidomide- or bortezomib-refractory disease

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2.2 Absorption and metabolism Once synthesized in the colon, UA can be absorbed through intestinal epithelial cells due to its lipophilic nature, subsequently entering the circulatory system via enterohepatic circulation