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Autopsy examinations on tissue samples from PD patients have shown glial cell activation, -synuclein aggregates, reduced SIRT1 activity, and increased expression of proinflammatory cytokines, such as IL-1, which requires activation of the NLRP3 inflammasome for maturation and activation (Codolo et al., Figure 1)

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia

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