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Moreover, PI3K/AKT/mTOR oncogenic cascade pathways are frequently dysregulated in several types of cancer, further enhancing lipogenic activities

The combination treatment of Tamarindus indica seeds extract with the tamoxifen (TMX) eliminates the cytotoxic effect in MCF-7 cells [27]

Smith AG, Singleton JR

Targeting the Wnt/-Catenin signaling pathway as a potential therapeutic strategy in renal tubulointerstitial fibrosis

Indeed, loss of glutathione peroxidase 4, a oxidation-resistant selenoprotein that utilizes GSH, leads to lipid peroxidation and subsequent ferroptosis, which is also found in epilepsy models ( The NADPH oxidase (NOX) family of enzymes is another relevant major source of ROS in the context of epilepsy as evidenced by activation of NOX2 by kainate-induced SE (Patel et al., 2005)