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HIPEC maximizes intraoperative drug exposure under hyperthermia, but it is typically delivered as a single-session bolus and its benefit can be sensitive to procedural heterogeneity and patient selection

Supplemental Material 1) for 3 days before and for the 9-day duration of the study

Preclinical studies demonstrate that tirzepatide promotes healthy adipose tissue expansion (hyperplasia rather than hypertrophy), increases adiponectin secretion, and enhances lipid uptake into adipocytes effectively improving the "metabolic sink" function of fat tissue

Lycopene: A powerful carotenoid found in red fruits that protects the skin from sun damage and improves skin texture

Conceptually, the dairy cow and its associated microbiota can be understood as a unified holobionta composite entity in which host and microbes co-regulate physiological homeostasis across multiple compartments 6