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Nrf2 activation attenuates oxidative stress by inducing anti-oxidant enzymes (e.g., HO-1, NQO1) which in turn reduce ROS levels

10.1126/science.aaw7567 146 TancharoenW.AungsuchawanS.PothacharoenP.BumroongkitK.PuanintaC.PangjaideeN.et al (2019)

From a safety perspective, although international regulatory bodies, such as the EFSA and WHO, have confirmed its safety within the recommended dosage range, some studies have suggested that long-term or high-dose intake may pose potential risks, including immune dysregulation, reproductive toxicity, and hepatic or renal metabolic burdens

In the regular milk you find in the grocery store, the A1 subtype is more common (2) because most cows in the United States have casein gene mutations that happened over the thousands of years of crossbreeding different kinds of cows