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The Janus kinase (JAK)/STAT pathway can modulate SASP and drugs with inhibitory effects on JAK alleviate senoinflammation in senescent cells, mitigate age-related organ malfunction, and improve physical activity in elder mice [142]

Some people may also experience headache, fatigue, or injection-site reactions such as redness or tenderness

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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

It essentially puts them in a state of suspended animation, stopping proliferation in its tracks