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Among mutations, the methylenetetrahydrofolate reductase, or the MTHFR gene mutation, is common

At the time of this review, clinical trials (e.g., NCT01267422) are currently underway to assess the safety and efficacy of rAAV2- ND4 treatment of LHON with G11778A mutation in humans

Several in vitro studies indicated that gaining autophagy activity in Ras -driven cancer cells shows a significant increase in the survival and progression of those cancer cells in several settings of metabolic stress (41)

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These antioxidant effects are particularly significant in pathologies such as neurodegenerative diseases and ischemiareperfusion injury, where oxidative imbalance plays a central pathogenic role [38, 39]