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Proponents of reassignment to APC 5624 stated that the higher APC assignment was warranted as CPT code 77412 is intended to account for the highest complexity therapy and such therapy requires additional time and incremental capital equipment resources to deliver multi-isocenter treatments and active motion management

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However, HDL-CEC decreased in transgender women (men to women) under estradiol hormone therapy, suggesting that reduction of testosterone and increase in estradiol may act synergistically in reducing HDL-CEC (210)