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E.JiangL.et al (2019)

Studies using exogenous oxidants such as tert -butyl hydroperoxide (tBH) and hydrogen peroxide (H 2 O 2 ) in cultured RPE cells highlight the role of oxidative stress in RPE cell death and premature senescence 8,9,10,11

Free Radic Biol Med 2000

In addition, increasing the stability of the cannabinoid using alcoholic formulations, as required by the physico-chemical characteristics of these compounds, is not recommended for applications to the skin, especially in dermatological conditions [174,213]