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TJs localised at the apex of the lateral membrane of IECs are often referred to as apical junction complexes and are composed of the apical-most TJs, adhesion junctions and desmosomes, each of which are involved in the separation of apical and basolateral membrane domains and maintaining gut barrier integrity (Turner and Turner 2010

The dose ladder is a strength dial, although receptor adaptation changes how each step feels over time

Certainly this is worth watching much much closer and something that could potentially doom non-selective amylin agonists overall if it turns out to be related to the calcitonin receptor