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The second pathway involves conversion by tryptophan 2,3-dioxygenase (TDO) in the liver and IDO(indoleamine 2,3-dioxygenase 1) in other tissues (brain, gastrointestinal tract, liver) into the kynurenine pathway, where approximately 90% of tryptophan is degraded [184,185,186]

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Moreover, all three studies that investigated PRP treatment in NOA [58, 61, 62] were assessed as having a moderate risk of bias, which may further contribute to the inconsistency in outcomes and limit the overall strength of the evidence

Reviews describe glutathione as part of cellular redox homeostasis and reactive species chemistry, with functions discussed across antioxidant systems, enzyme cofactors, and signaling models [4] [5] [7]