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Collectively, these findings demonstrate that VVZ-2471 effectively inhibits both 5-HT2aR and mGluR5-mediated synaptic activity and signaling responses in neurons

Attention to background strain is essential for metabolic research: C57BL/6 and the international knockout mouse consortium

To further investigate the impact of iAstrocytes on neuronal function, we generated excitatory induced neurons (iNs) from hESCs and co-cultured them with iAstrocytes from BD patients (Fig

Based on the scRNA-seq findings suggesting that Lgr5 + populations harbor the potential to become revSCs, we performed a reconstitution assay using Lgr5 EGFP-IRES-CreERT2/+ mice 2 to evaluate fetal reversion capacity among distinct cell populations under homeostatic conditions, stratified by their stemness (Fig