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In addition, as mentioned previously that MMP-2 was significantly increased in leiomyoma cells, Curcumae rhizoma was also reported to inhibit the expression of MMP-2 which could also contribute to its use in the treatment of UF ( Curcumae rhizoma was also able to induce apoptosis by decreasing the level of BCL-2 and at the same time inhibit the phosphorylation of the AKT/NF-B pathway ( When both of these herbs are used together (known as CRSR, CR:SR = 1:1) in the treatment of UF, the uterine mass was found to be decreased significantly with a significantly lowered progesterone and estradiol level

For people without additional risk factors, such as genetic variants, kidney disease, or intestinal fat malabsorption, the increased dietary intake is usually excreted through the kidneys without incident

10.2337/db11-1019 142 TongJ