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Gordon MF, Brashear A, Elovic E, Kassicieh D, Marciniak C, Liu J, Turkel C,

Preclinical studies demonstrated that the compound effectively inhibited KDAC activity under low-oxygen conditions, leading to DNA damage, cell-cycle arrest, and apoptosis in cancer cells

J Biol Inorg Chem 31 , 239277 (2026)

For example, CNF-1 was reported to induce inflammatory responses and produce chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 3 (MIP-3) (Munro et al., 2004)

That mentioned, isolating these proceedings and associating them with drug metabolism, more importantly, health outcomes is the main challenge