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Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

The antioxidant potential of KD may be due to its impact on the Nrf2 pathway

Furthermore, it was shown that senolytic vaccination improved normal and pathological phenotypes associated with aging, and extended the male lifespan of progeroid mice (79)